Calcium Handling Abnormalities in Atrial Fibrillation as a Target for Innovative Therapeutics

    loading  Checking for direct PDF access through Ovid

Abstract

Abstract:

Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca2+ (calcium) handling as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca2+ handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.

Related Topics

    loading  Loading Related Articles