Calcium Handling Abnormalities in Atrial Fibrillation as a Target for Innovative Therapeutics

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Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca2+ (calcium) handling as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca2+ handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.

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