Facebook
Twitter
LinkedIn
Email
 |
Checking for direct PDF access through Ovid | |
Excerpt
BACKGROUND: HSD has been shown to be effective in resuscitating hypovolemia due to hemorrhage. Common hemodynamic findings after the injection of HSD in hemorrhagic shock are the restoration of cardiac output, increased blood pressure, and improvement of peripheral circulation. Some mechanisms by which HSD maintains circulation in hemorrhagic shock have been proposed: rapid shift of fluid from intracellular to extracellular space, improved peripheral perfusion, and increased cardiac contractility. However, conflicting data exist regarding the positive effect of HSD on cardiac contractility after hemorrhagic shock.
METHODS: Hemorrhagic shock was created by exsanguination of 31.4 +/- 8ml/kg and mean BP was then maintained at 50mmHg for 30 minutes. The HSD group (n=6) received HSD (4ml/kg) and the saline group (n=6) received normal saline (40ml/kg) after shock. Cardiac functions were measured in both groups using the left ventricular end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW) during the experimental period: before shock, just after shock, just after resuscitation, and 1h and 2h after resuscitation.
RESULTS: Hemodynamic parameters did not differ significantly between the 2 groups. The slope of PRSW in the HSD group was significantly decreased as compared with that in the saline group using ANOVA (p < 0.05). The slopes of ESPVR did not differ significantly between the 2 groups.
CONCLUSION: HSD seems to be an effective resuscitation fluid after hemorrhagic shock because the volume required to maintain circulation is smaller than that of normal saline. However, our data show that HSD does not enhance cardiac contractility after hemorrhagic shock.
