Drug-associated Organizing Pneumonia: High-resolution CT Findings in 9 Patients

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Abstract

Objective

To assess the high-resolution computed tomography appearances of drug-associated organizing pneumonia (OP).

Materials and Methods

Nine patients with clinical and biopsy proven drug-associated OP were included in the study. High-resolution computed tomography exams were retrospectively reviewed by 2 observers for the presence, extent, and distribution of parenchymal abnormalities.

Results

The commonest findings consisted of air space consolidation (n=8) and ground-glass opacification (n=7). The air space consolidation was bilateral and asymmetric in 7 patients, symmetric in 1 patient and in all cases involved mainly the peribronchial or subpleural regions or both. The ground-glass opacities were predominantly bilateral and asymmetric in 6 patients and unilateral in 1 patient. They had a patchy distribution in 4 patients, were diffuse in 2 patients, and subpleural in 1 patient.

Conclusion

Drug-associated OP most commonly presents with bilateral, asymmetrical air space consolidation in a predominantly peribronchial and subpleural distribution.

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