From the *Institute for Clinical Evaluative Sciences, Toronto, Canada; the †Department of Health Policy, Management and Evaluation/Clinical Epidemiology, University of Toronto, Toronto, Canada; the ‡Department of Public Health Sciences, University of Toronto, Toronto, Canada; the §Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Canada; the ¶Montreal Heart Institute, University of Montreal, Montreal, Canada; and the ∥Department of Medicine, Sunnybrook and Women's College Health Science Centre, Toronto, Canada.