Issn Print: 0195-9131

Publication Date: 1997/05/01


Print

REDUCED MYOSIN HEAVY CHAIN I IN SKELETAL MUSCLE IN CHRONIC HEART FAILURE: RELATIONSHIP TO NEUROHUMORAL FACTORS 1506

B D Duscha; M J Sullivan; F Schachat; C Kuhn; J Blank; M Briggs; R Symanski; T Zimmermann

    loading  Checking for direct PDF access through Ovid

Excerpt

Previous studies have demonstrated alterations in skeletal muscle (SM) in patients with chronic heart failure (CHF) which may contribute to decreases in exercise tolerance. In order to evaluate the relationship of neurohumoral factors to alterations in SM in CHF we evaluated relative myosin heavy chain(MHC) subtype from vastus lateralis muscle biopsies in 13 patients with CHF(LVEF 35±4) and 7 age matched sedentary normal subjects. Peak VO2 was significantly reduced in CHF vs normals (21±5 vs 15±3 ml/kg/min: p<0.05). Results for MHC, aldosterone (ALDO), norepinephrine (NE), epinephrine (EPI), renin, and cortisol are shown below(*p<0.05 CHF vs Normals): Table
Thus CHF patients have decreased MHC I and increased type IId MHC when compared to normals accompanied by increased neurohumoral activation. Percent MHC I was not related to exercise tolerance or LVEF in patients with CHF. There was no relationship with MHC I and aldosterone, NE, EPI, or cortisol. However, there was a trend for an inverse relationship of plasma renin and MHC I in CHF (r=0.63, p<0.09). Renin was also related to MHC IIa content in CHF(r=0.68, p<0.07). Our results indicate that significant alterations in MHC are present in patients with CHF which are not related to enhanced sympathetic activity. Our findings raise the possibility that the reninangiotensin system may play a role in alterations of skeletal muscle in this disorder.

Related Topics

    loading  Loading Related Articles