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Excerpt
The insular cortex has been implicated as an important cerebral cortical site of cardiovascular regulation. The purpose of this study was to determine if patterns for right and left insular cortex activation were altered over time during static handgrip (SHG) exercise and also during post-exercise cuff occlusion (PECO). Four subjects performed bouts of static handgrip at 25% MVC on separate days. Data for HR, MAP, RPE and regional cerebral blood flow (rCBF) using a retained blood flow tracer were assessed at rest, minute 2 and minute 4 of SHG. Two additional subjects performed SHG followed by PECO to assess the role of muscle metaboreflex input towards insular activation. A Friedmans analysis showed a significant increase (p < 0.05) in rCBF distribution for both the right (5.9 ±0.8%) and left (6.0 ±0.9%) insular cortices at 4 minutes during SHG. There were also significant increases (p < 0.05) for HR (to 89 ±4 bpm), MAP (to 128 ±4 mmHg) and RPE (from 6 to 15.8 ±1.3 units) at 4 minutes. Although MAP was sustained during PECO (123 ±3.3 mmHg), there was no significant insular activation during PECO. These findings suggest that activation of both right and left insular cortices during static handgrip may be related to increased levels of central command.
