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Excerpt
The effects of exercise training, chronic administration of clenbuterol(β&2-adrenergic agonist), and the combination of these two treatment on body fat content and muscle enzyme activities were investigated. Forty male Sprague-Dawley rats were randomly assigned to one of four treatment groups: sedentary control(CON), clenbuterol(CL), exercise trained(TR), or exercise trained/clenbuterol(TR+CL). The training protocol consisted of running on motor-driven treadmill up an 8% grade, 5 days/wk for 8 weeks. Rats receiving clenbuterol were intubated with 0.8 mg/kg body wt/day dissolved in deionized water. Exercise training and clenbuterol administration significantly not only reduced the body fat content as evidenced by the decreasing retroperitoneal fat weight, but also increased the skeletal muscle mass without the changes of growth rate. The combined effect of these two treatment in increasing the muscle mass was additive, but in reducing the fat content, it was not additive. Chronic clenbuterol treatment significantly reduced the hexokinase and citrate synthase activities in skeletal muscle. These decreased enzyme activities significantly reduced endurance performance. Thus, the results of the current study indicate that the effects of clenbuterol treatment are the same as the effects of exercise training in body composition, but each of clenbuterol treatment and training inversely affects the changes in skeletal muscle enzyme activities of normal rats. Supported by Korea Research Foundation.
