LIMITED AUGMENTATION OF LEG O2 EXTRACTION DURING GRADED DYNAMIC EXERCISE IN SEDENTARY WOMEN

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Abstract 1553
Most previous studies that examined leg blood flow and O2 uptake responses to exercise, including our own, have primarily utilized trained men as subjects. These subjects typically display progressive femoral venous O2 desaturation, widening of the leg arterial-venous O2 content difference, and a linear rise in leg blood flow with increasing cycle ergometer workloads. To determine the effects of endurance training per se on these parameters, we recently subjected five young untrained volunteers to 10-weeks of bike interval training (6×5 min @ 90-100% VO2max, 5 d/wk). Pre-training results in 4 sedentary women (27-36 yr), compared with previous data for 6 chronically endurance-trained men (i.e., means for trained men given in parentheses) were: (Table) In contrast to the trained men, these sedentary women did not augment leg O2 extraction with increasing workloads. Post-training results in 1 woman completed thus far indicate a reduced leg blood flow and progressively lower femoral O2 saturations (thus higher a-vO2 differences) across these same workloads. Thus, we speculate that fitness, in addition to gender-related differences (e.g., leg composition) might be responsible for the limited leg O2 extraction response seen in sedentary women.
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