β-hydroxy-β-methylbutyrate ingestion, Part II: effects on hematology, hepatic and renal function

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Abstract

Purpose:

The purpose of this investigation was to examine the effects of differing amounts of β-hydroxy-β-methylbutyrate (HMB), 0, 36, and 76 mg·kg-1·d-1, on hematology, hepatic and renal function during 8 wk of resistance training.

Methods:

Thirty-seven, untrained collegiate males and were randomly assigned to one of the three groups, 0, 38, or 76 mg·kg-1·d-1. Resistance training consisted of 10 exercises, performed 3 d·wk-1 for 8 wk at 80% of their 1-repetition maximum. Blood and urine was obtained before training, 48 h after the initial session, 1 wk, 2 wk, 4 wk, and at 8 wk of resistance training. Blood was analyzed for glucose, blood urea nitrogen, hemoglobin, hepatic enzymes, lipid profile, total leukocytes, and individual leukocytes. Urine was analyzed for pH, glucose, and protein excretion.

Results:

The 38 mg·kg-1·d-1 group had a greater increase in basophils compared with 0 or 76 mg·kg-1·d-1 groups (P < 0.05). No difference occurred in any other blood and urine measurements.

Conclusion:

These data indicate that 8 wk of HMB supplementation (≤76 mg·kg-1·d-1) during resistance training had no adverse affects on hepatic enzyme function, lipid profile, renal function, or the immune system.

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