The purpose of this investigation was to examine the effects of differing amounts of β-hydroxy-β-methylbutyrate (HMB), 0, 36, and 76 mg·kg-1·d-1, on hematology, hepatic and renal function during 8 wk of resistance training.Methods:
Thirty-seven, untrained collegiate males and were randomly assigned to one of the three groups, 0, 38, or 76 mg·kg-1·d-1. Resistance training consisted of 10 exercises, performed 3 d·wk-1 for 8 wk at 80% of their 1-repetition maximum. Blood and urine was obtained before training, 48 h after the initial session, 1 wk, 2 wk, 4 wk, and at 8 wk of resistance training. Blood was analyzed for glucose, blood urea nitrogen, hemoglobin, hepatic enzymes, lipid profile, total leukocytes, and individual leukocytes. Urine was analyzed for pH, glucose, and protein excretion.Results:
The 38 mg·kg-1·d-1 group had a greater increase in basophils compared with 0 or 76 mg·kg-1·d-1 groups (P < 0.05). No difference occurred in any other blood and urine measurements.Conclusion:
These data indicate that 8 wk of HMB supplementation (≤76 mg·kg-1·d-1) during resistance training had no adverse affects on hepatic enzyme function, lipid profile, renal function, or the immune system.