Issn Print: 0195-9131
Publication Date: 2001/05/01
RESTING BLOOD PRESSURE RESPONSE TO STRENGTH TRAINING MAY DEPEND ON ANGIOTENSINOGEN (-20) GENOTYPE
B F. Hurley; G F. Martel; S M. Roth; J L. Fleg; R E. Ferrell
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Author Information: University of Maryland, College Park, Maryland
Excerpt
To determine the relationship between angiotensinogen (AGT) genotype and blood pressure (BP) response to strength training (ST), 33 older men (N = 24) and women (N = 9) were studied before and after a 24 wk ST program. Genomic DNA was analyzed for genetic variants of the AGT gene in the - 20 position (AGT20). Twenty-one subjects (15 men and 6 women) were homozygous for the A allele (A/A) and 12 subjects (9 men and 3 women) were heterozygotes (A/C). BP measurements were taken following 5 min of seated rest on 6 separate days both before and after the ST program and averaged for each condition. Keiser K-300 air powered machined were used for training and for the one-repetition maximum (1 RM) strength testing. The ST program resulted in substantial increases in 1 RM strength in upper (P < 0.001) and lower body (P < 0.001) muscle groups in both genotype groups. There were no significant differences between the A/A and A/C genotype groups for age (66 +/− 1 vs 64 +/− 2 yrs), height, weight, % fat, or VO2 max at baseline. Despite the fact that only the A/C genotype group reduced their body fat significantly with ST (32 +/− vs 28 +/− 3% fat), only the A/A group reduced both systolic (133 +/− 2 vs 127 +/− 2 mm Hg, P < 0.05) and diastolic BP (80 +/− 2 vs 76 +/− 1 mm Hg, P < 0.05) with St. No significant changes were observed in the A/C group for systolic (123 +/− 3 vs 124 +/− 3 mm Hg) or diastolic BP (76 +/− 2 vs 77 +/− 2 mm Hg). These data indicate that the angiotensinogen (−20) genotype may influence BP response to ST in older men and women.
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