Issn Print: 0195-9131
Publication Date: 2002/05/01
ARTERIAL BAROREFLEX SENSITIVITY IS NOT ENHANCED IN EXERCISE TRAINED MEN: A NOVEL MEASUREMENT APPROACH
D D. Christou; D R. Seals; L F. Shapiro; P P. Jones
+ Author Information
Author Information: University of Colorado, Boulder, CO
Excerpt
The evidence that arterial baroreflex sensitivity (BRS) is enhanced in the aerobic exercise trained state is inconsistent, and may relate to different methods used to measure BRS. We developed a novel approach for determining BRS, to test the hypothesis that it is enhanced in exercise trained men. With ganglionic blockade (GB), autonomic cardiovascular reflexes are interrupted. During simultaneous infusion of phenylephrine (phe), the slope of the increase in blood pressure (BP) per plasma concentration of phe (ΔBP/[phe]) is greater than in the intact autonomic state due to the absence of baroreflex counter-regulation. Thus, the magnitude of increase in ΔBP/[phe] during GB reflects the BRS.
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