Issn Print: 0195-9131
Publication Date: 2002/05/01
RECOVERY OF CO2 WITH LACTATE INFUSION DURING REST AND EXERCISE -” THE LACTATE CLAMP”
B F. Miller; J A. Fattor; K A. Jacobs; F Navazio; G A. Brooks
+ Author Information
Author Information: Exercise Physiology Lab, University of California-Berkeley, Berkeley, CA.
Excerpt
As a follow up to a larger study examining training induced changes in gluconeogenic capacity, we employed an exogenous Na-lactate:lactic acid (70:30) infusion during periods of rest and exercise in moderately active subjects. Others have previously shown that RER decreases during rest with Na-lactate infusion due to the generation of HCO3−. Presumably the introduction of Na+ with lacate increases the NaHCO3 content of blood and thus the body HCO3− pool. The increased HCO3− pool leads to decreased pulmonary CO2 elimination and consequently a decrease in RER or 13C-tracer infusion.
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