Issn Print: 0195-9131
Publication Date: 2003/05/01
CONTRIBUTION OF NITRIC OXIDE TO BASAL LEG VASCULAR TONE IN SPINAL CORD-INJURED INDIVIDUALS
M Kooijman; M W. Bleeker; G A. Rongen; P Smits; M T. Hopman
+ Author Information
Author Information: Department of Physiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Excerpt
In spinal cord-injured individuals (SCI), loss of supraspinal control of somatic efferents and the subsequent extreme deconditioning of leg muscles appears to be associated with vascular adaptations. The previously observed increase in basal leg vascular tone in SCI may be due to structural vascular changes. However, functional vascular adaptions, like for example a blunted endothelial release of nitric oxide (NO), form an alternative explanation.
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