Issn Print: 0195-9131
Publication Date: 2003/05/01
EXERCISE-INDUCED NUCLEAR EXPORT OF HDAC5 IN HUMAN SKELETAL MUSCLE
S L McGee; L J. Cluberton; M Hargreaves
+ Author Information
Author Information: Exercise, Muscle and Metabolism Unit, Deakin University, Burwood, Australia
Excerpt
Chromatin remodelling plays a critical role in controlling gene expression in eukaryotic cells. Histone deacetylases (HDACs) and histone acetyl transferases (HATs) control the acetylation state of histones and thus regulate the access of transcriptional regulators to DNA. The activity of these enzymes appears to be regulated by their cellular localisation. An acute bout of exercise is known to enhance the expression of several metabolic genes, including GLUT-4. The transcription factor myocyte enhancer factor 2 (MEF2) is required for GLUT-4 gene expression and is also repressed by HDAC5, suggesting that the cellular localisation of HDAC5 could be modulated by exercise.
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