Issn Print: 0195-9131
Publication Date: 2005/05/01
Heart Failure-induced Muscle Atrophy Is Independent Of Protein Kinase B/Mammalian Target Of Rapamycin Signaling: 402 Board #2
Thomas H. Reynolds; Kristen Laurenson; Timothy I. Musch
+ Author Information
Author Information: Ithaca College, Ithaca, NY.
Excerpt
Skeletal muscle atrophy is a common consequence of chronic heart failure. Although the extent of muscle atrophy due to chronic heart failure greatly impacts functional capacity, the mechanisms responsible for heart failure-induced muscle atrophy are not established. The protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway plays a predominant role in regulating skeletal muscle size by controlling mRNA translation initiation and protein synthesis. Whether or not a decline in the activity of the PKB/mTOR signaling pathway is associated with heart failure-induced muscle atrophy is unknown.
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