Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient.Patient concerns:
10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate.Diagnoses:
In this study, we treated 9 patients (25–86 years) with rCDI.Interventions:
From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime.Outcome:
Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas.Lessons:
FMT capsules based on multiple donors are highly efficient in patients with rCDI.