Male asymptomatic hyperuricemia patients display a lower number of NKG2D+ NK cells before and after a low-purine diet

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Background:Aberrant activation of the immune system has been reported in asymptomatic hyperuricemia (HUA) patients. However, very few studies have elucidated the role of natural killer (NK) cells in this disease.Methods:In this study, we evaluated the relationship between NK cells and HUA in 16 control subjects and 20 patients, who were all on a low-purine diet. We analyzed the number of circulating NK cells, its subsets, interferon-γ+, and CD107+ NK cells, by flow cytometry, before and after 4 and 24 weeks of diet control. We also assessed the potential association of the NK cells with clinical measures.Results:The patients consistently had a lower number of NKG2D+ NK cells before and after low-purine diet, even the serum uric acid (SUA) levels <7 mg/dL after diet control. Moreover, a lower number of NK cells and a higher number of CD107a+ NK cells were observed on recruitment. Low-purine diet was benefit on the improvement of the SUA levels, body mass index (BMI), and the number and functions of NK cells. Furthermore, the number of CD3CD56+ NK cells and NKG2D+ NK cells negatively correlated with the BMI before and after diet control.Conclusion:The consistent lower number of NKG2D+ NK cells and correlated with BMI before and after low-purine diet may be involved in the occurrence and development of HUA.

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