Issn Print: 0143-3636

Publication Date: 1986/12/01


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Technegas - a new ventilation agent for lung scanning

WILLIAM M. BURCH; PAUL J. SULLIVAN; CHRISTOPHER J. MCLAREN

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Author Information: Department of Medicine and Clinical Science, John Curtin School of Medical Research, Australian National University and department of Nuclear Medicine, Royal Canberra Hospital, Acton, ACT 2601, Australia

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Abstract

Summary

A simple process using technetium-99m generator eluate in a graphite crucible at 2500° C, produces a structured ultra-fine dispersion of labelled carbon. Particle sizes are 5.0 run (0.005μm) and less and adhere to the walls of the alveoli on inhalation. Penetration characteristics are gas-like and the radioactivity per litre of carrier argon allows single breath inhalations of a diagnostic dose.

Over 190 patients have been studied including 50 within a formal clinical trial with xenon-133. Results of tomography, dynamic inhalation, and image subtraction using this new agent-'Technegas' - are presented.

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