Aspirin for Primary Prevention of Cardiovascular Disease (Revisited)

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When the use of aspirin for primary prevention of cardiovascular diseases was last reviewed in The Medical Letter,1 only one placebo-controlled prospective trial was available: the (male) Physicians’ Health Study.2 Last year, a second large, randomized, placebo-controlled study was reported as part of the Women’s Health Study.3 Recently a sex-specific meta-analysis of 6 trials, including these two, was published.
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