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Perioperative Morbidity and Mortality Among Human Immunodeficiency Virus–Infected Women Undergoing Cesarean Delivery

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Abstract

OBJECTIVE:

To determine whether human immunodeficiency virus (HIV)–infected women have a higher rate of postcesarean morbidity and mortality compared with women without HIV infection.

METHODS:

A secondary analysis was performed of women with singleton gestations undergoing cesarean delivery with known HIV status. Data were collected as part of a prospective 4-year (1999–2002) observational study and analyzed using logistic regression. Women were surveyed for a large number of intraoperative complications, common perioperative morbidities, and uncommon maternal complications.

RESULTS:

There were 378 HIV-infected and 54,281 uninfected women who met criteria. Patients infected with HIV were more likely to have postpartum endometritis (11.6% compared with 5.8%, P<.001), require a postpartum blood transfusion (4.0% compared with 2.0%, P=.02), develop maternal sepsis (1.1% compared with 0.2%, P<.001), be treated for pneumonia (1.3% compared with 0.3%, P=.001), and to have a maternal death (0.8% compared with 0.1%, P<.001). After controlling for potential confounders, patients with HIV infection were more likely to have one or more postpartum morbidities (odds ratio 1.6, 95% confidence interval 1.2–2.2).

CONCLUSION:

Women with HIV infection undergoing cesarean delivery are at increased risk for perioperative morbidity and maternal mortality.

LEVEL OF EVIDENCE:

II

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