Diagnosis and Management of Clostridium Perfringens Sepsis and Uterine Gas Gangrene

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The progression of Clostridium perfringens endomyometritis to gas gangrene is a rare, but greatly feared complication in the obstetrical patient. While endometritis following cesarean delivery is a common complication, recognition of C. perfringens as the pathogen as well as its progression to gas formation in the myometrium is essential to the survival of the patient. We present a patient that we recently cared for, and review the bacteriology, clinical diagnosis, and management.

Target Audience: Obstetricians & Gynecologists, Family Physicians

Learning Objectives: After completion of this article, the reader will be able to list the most common organisms that cause gas gangrene, to explain the pathophysiology of gas gangrene infections, to describe the clinical findings in a patient with gas gangrene of the uterus, and to outline potential treatment options for the patient with gas gangrene.

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