Pharmacokinetics and pharmacodynamics of antibiotics in otitis media
The pharmacology of antimicrobial chemotherapy can be divided into two components. Pharmacokinetics deals with the absorption, distribution and elimination of antimicrobials. These factors, combined with the dosing regimen, determine the time course of drug concentrations in serum and in body tissues and fluids. With otitis media one is interested in the time course of antimicrobial concentrations in middle ear fluid and in the surrounding mucosal tissues. Pharmacodynamics, on the other hand, deals with the relationship between concentrations at sites of infection and the antimicrobial effect. This report will provide a brief review of the interrelationship between pharmacokinetics and pharmacodynamics for the antimicrobial therapy of otitis media. Special emphasis will be given to the therapy of infections with penicillin-intermediate and penicillin-resistant Streptococcus pneumoniae.