PMID: 10959753
Issn Print: 0891-3668
Publication Date: 2000/08/01
ACTIVATION OF PERIPHERAL BLOOD CD8+ T CELLS IN ADENOVIRUS INFECTION
Tomoyo Matsubara; Tamotsu Inoue; Norimichi Tashiro; Kumiko Katayama; Takashi Matsuoka; Susumu Furukawa
Excerpt
Adenoviruses are responsible for a varied array of illnesses in children. 1 Most commonly they are associated with respiratory illness and gastroenteritis, but cardiac, neurologic, cutaneous, urinary and lymphatic manifestations also occur frequently. The incidence of adenoviral infection peaks in infants and children between 6 months and 5 years of age. Although fatalities are rare they are associated with infections by certain serotypes (particularly serotype 7). Although alterations in leukocytes are not common, a decrease in lymphocytes before or at the onset of clinical illness and an increase in neutrophils early in the disease have been observed. 2 However, there have been few reports on numerical change of peripheral blood immunocompetent cells in adenovirus infection.
We report here a case of pneumonia, complicated with severe bronchiectasia as a sequela, by adenovirus type 7 infection. An adenovirus type 7 pneumonia patient showed immunologic findings characterized by a marked increase in serum interferon-gamma (IFN-gamma) levels, activated peripheral blood CD8+ T cells and IFN-gamma-producing CD3+ T cells. In addition, we investigated peripheral blood lymphocyte subsets and serum concentrations of IFN-gamma in patients with upper respiratory diseases caused by other types of adenovirus infection.
Facebook
Twitter
LinkedIn
Email
