The Pediatric Infectious Disease Journal. 25(6):562-564, JUNE 2006

DOI: 10.1097/01.inf.0000219401.70804.1a

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PMID: 16732160

Issn Print: 0891-3668

Publication Date: June 2006


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LINEZOLID-RESISTANT STAPHYLOCOCCUS AUREUS IN TWO PEDIATRIC PATIENTS RECEIVING LOW-DOSE LINEZOLID THERAPY

Susanne Roberts;Alexandra Freeman;Susan Harrington;Steven Holland;Patrick Murray;Adrian Zelazny;

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Abstract

We report 2 sisters with hyper-IgE syndrome treated with daily suppressive dosages of linezolid (LZD) who developed LZD-resistant Staphylococcus aureus carrying the G2576T mutation in the 23S rRNA gene. Molecular typing suggested transmission of the resistant strain from one sister to the other. LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy.

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