PERTUSSIS VACCINE EFFECTIVENESS IN REDUCING CLINICAL DISEASE, TRANSMISSIBILITY AND PROPORTION OF CASES WITH A POSITIVE CULTURE AFTER HOUSEHOLD EXPOSURE IN BRAZIL


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Abstract

In household outbreaks of pertussis, children <5 years of age who received at least 3 doses of vaccine had 12% less clinical disease; vaccinated cases were 63% less culture-confirmed and transmitted infection to 62% fewer contacts. Three doses of pertussis vaccine are likely to decrease circulation of Bordetella pertussis by reducing the proportion of bacteriologically positive cases and transmissibility.

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