FALSE-NEGATIVE HISTOPLASMA ANTIGEN IN ACUTE PULMONARY HISTOPLASMOSIS: THE VALUE OF URINARY CONCENTRATION BY ULTRAFILTRATION AND HEAT DENATURATION OF SERUM PROTEINS IN DETECTION OF HISTOPLASMA ANTIGEN


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Abstract

We report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic. A provisional diagnosis of histoplasmosis was established by using laboratory methods that increase the sensitivity of the antigen assay using ultrafiltration of urine and ethylenediaminetetraacetic acid/heat denaturation of serum proteins.

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