Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

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We report a case of lower respiratory tract infection with human bocavirus 1 (HBoV1) in an immunodeficient 6-month-old boy leading to respiratory failure with fatal outcome. Polymerase chain reaction of serum/tracheal secretions revealed exceptionally high HBoV1-DNA levels and immunoassays showed seroconversion indicating an acute primary HBoV1 infection. All assays for other pathogens were negative, strongly suggesting that HBoV1 was the causative agent in this case.

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