DOI: 10.1097/01.prs.0000371753.47946.94

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Issn Print: 0032-1052

Publication Date: 2010/06/01


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17: IL-10 AND DONOR ANTIGEN PULSED TOLEROGENIC DENDRITIC CELL PRETREATMENT IN COMPOSITE TISSUE ALLOTRANSPLANTATION

SC Eun; JH Kim; MJ Kim; CY Heo; SH Lee; JL Park; RM Baek; H Chang; KW Minn; SW Kim; TH Choi

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Excerpt

Prevention of acute rejection in composite tissue allotransplantation without continuous immunosuppression is paramount important in the transplantation field. Recently dendritic cells (DC) gained considerble attention as antigen presenting cells that are also capable of immunologic tolerance induction. This study assesses the effect of alloantigen-pulsed DC in induction of survival increase in a rat hindlimb allotransplantation model.
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