DOI: 10.1097/01.prs.0000387232.37013.31
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Issn Print: 0032-1052
Publication Date: 2010/08/01
LP37: EXPRESSION OF ANTIMICROBIAL PEPTIDES IN MAXILLOFACIAL SURGICAL SITE INFECTIONS
N. Rohleder; L. Steinstraesser; R. Hasler; F. Jacobsen; M. Kesting
+ Author Information
Author Information: Technische Universität München, Department of Oral and Maxillofacial Surgery, München, Germany
Excerpt
Increasing numbers of antibiotics have lost efficiency because of bacterial resistance. Consequences can be severe when surgical wounds become infected during postoperative care. Natural peptide antibiotics, the so-called host defence peptides (HDP), have been investigated since the 1990s in a search for alternative treatment strategies. HDP build up a protection shield against pathological microorganisms, especially in human epithelia. The use of HDP is currently being discussed as a new antimicrobial therapy strategy. Accordingly, a profound knowledge of the quantitative relationships of the effectors is essential. The objective of this study was to assess differences in HDP expression between postoperatively inflamed (from surgical site infections) and healthy skin epithelium.
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