DOI: 10.1097/01.prs.0000430131.48863.ec

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Issn Print: 0032-1052

Publication Date: 2013/05/01


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Abstract 189: LOSARTAN AND TREATMENT OF SCAR CONTRACTURE

Tosan Ehanire; J Bond; L Ren; H Levinson; L Chen

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Excerpt

Following dermal injury, the subsequently formed scar can progressively shorten and form a contracture. Scar contracture limits range of motion and interferes with daily living, Contracture is mediated by fibroblast migration and contractility that leads to tissue contraction. Here we study the role of angiotensin II (AngII) and its receptors ATr1 and ATr2 in contracture by using human tissue, in vivo model of contraction, and in vitro primary human fibroblast assays.
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