DOI: 10.1097/01.prs.0000445122.92738.19

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PMID: 25942200

Issn Print: 0032-1052

Publication Date: 2014/03/01


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Abstract 89: Novel Targeting of the Alk-2 Receptor Using the Cre/lox System to Enhance Osseous Regeneration by Mesenchymal Stem Cells

Cameron Brownley; Shailesh Agarwal; Jonathan Peterson; Eboda Oluwatobi; Kavitha Ranganathan; Stewart C Wang; Yuji Mishina; Steven R Buchman; Benjamin Levi

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Excerpt

There is a significant need for readily available autogenous tissue to aid in bone regeneration without causing a donor-site defect. Most studies focus on the ability of bone morphogenetic protein ligands (BMP-2 and 7) to stimulate the Bmpr1b receptor (ALK-6). The ACVR1 gene is often overlooked, but provides instructions for making the activin receptor type I protein (ALK-2), a protein member of the Bmpr1 family. When the ALK-2 receptor is overexpressed globally, patients develop fibrodysplasia ossificans progressive. We believe this highly osteogenic phenotype can be harnessed in adipose derived stem cells (ASCs) to improve bone tissue engineering. Our goal here was to demonstrate that ALK-2 may serve as a novel target to 1) improve in vitro ASC osteogenic differentiation and 2) enhance in vivo bone regeneration and calvarial healing.
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