Sialyl Lewisa Ganglioside in Pancreatic Cancer Tissue Correlates with the Serum CA 19-9 Level


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Abstract

SummaryCA 19–9 ganglioside antigen was extracted from the tumors of 16 patients with pancreatic cancer and the antigen was confirmed by mass spectrometry to be a sialyl Lewisa ganglioside. Ductal adenocarcinomas from four patients, two whose Lewis blood phenotype was Le(a- b-), one with undifferentiated carcinoma, and one with an acinar cell carcinoma, did not contain detectable amounts of sialyl Lea ganglioside. A significant correlation was found between serum CA 19–9 levels and the recovery of ganglioside antigen from respective tumors, but not tumor burden.

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