Issn Print: 0885-3177
Publication Date: 2006/11/01
NORMALIZATION OF INSULIN RESISTANCE & IMPAIRED CCK STIMULATED PANCREATIC SECRETION IN eNOS (−/−) MICE BY PIOGLITAZONE. POTENTIAL FOR CORRECTING HUMAN ENDOCRINE & EXOCRINE DISORDERS?
R. C. Reddy; Y. Hao; S. H. Lee; C. Owyang; M. J. DiMagno
Excerpt
Recently we showed that eNOS (endothelial NO synthase) maintains in vivo murine pancreatic secretion response to carbachol and CCK-8. Because eNOS also maintains insulin sensitivity and modulates pancreatic blood flow (PBF), our aims were to detemine if pioglitazone (insulin sensitizer) reduces insulin resistence, improves exocrine pancreatic secretion and if changes in pancreatic secretion are coupled to PBF.
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