Cytokine Genotypes in Acute Pancreatitis: Association With Etiology, Severity, and Cytokine Levels in Blood

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Abstract

Methods:

Patients with AP were included prospectively. Severity of the disease was determined according to Atlanta classification. Serum levels of these cytokines were determined within the first 72 hours after the onset of symptoms. The following polymorphisms were determined by polymerase chain reaction: IL-1a −889, IL-1b +3954, IL-1b −511, variable number tandem repeats, IL-6 −174, IL-6 −597, IL-10 −592, TNF-α 308, TNF-α 238, and TNF-B250.

Results:

Eighty-four patients were included. The GA genotype of the TNF-α 238 polymorphism was associated with more frequent respiratory failure and shock than the GG genotype. Gallstone pancreatitis was associated with the CC genotype of the IL-6 −174 CC polymorphism.

Conclusions:

AG genotype of the TNF-α 238 polymorphism is associated with organic failure in patients with AP. The CC genotype of the IL-6 174 polymorphism is associated with biliary etiology of acute pancreatitis.

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