LONG-TERM POTENCY, STERILITY, AND STABILITY OF VANCOMYCIN, CEFTAZIDIME, AND MOXIFLOXACIN FOR TREATMENT OF BACTERIAL ENDOPHTHALMITIS

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Abstract

Purpose:

To determine the long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes for intravitreal injection.

Methods:

Experimental study. Vancomycin 1 mg/0.1 mL, ceftazidime 2 mg/0.1 mL, and moxifloxacin 160 μg/0.1 mL were compounded and prepared in 1-mL polypropylene syringes and stored at 4°C, −20°C, and −80°C. Antibiotic potency, sterility, pH, osmolality, and concentration were tested at baseline and at 1, 2, 4, 8, 12, and 24 weeks after preparation.

Results:

Potency, sterility, and stability were preserved for all 3 antibiotics at all temperatures out to 24 weeks, although there was a trend toward reduced potency at Week 24 for vancomycin and ceftazidime stored at 4°C. The largest zones of inhibition for Staphylococcus epidermidis and S. aureus were consistently demonstrated by moxifloxacin.

Conclusion:

Vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes retain potency, sterility, and stability out to 24 weeks when stored at −20°C or −80°C. The results of this study may have important implications for the current management of endophthalmitis.

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