MyD-88 L265P MUTATIONS ARE PRESENT IN SOME CASES OF VITREORETINAL LYMPHOMA


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Abstract

Purpose:To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas.Methods:The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation.Results:The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases.Conclusion:Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

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