Tests of BufferGel for Contraception and Prevention of Sexually Transmitted Diseases in Animal Models


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Abstract

BackgroundBufferGel is a novel spermicidal and microbicidal gelformulated to maintain the natural protective acidity of the vagina byacidifying semen, which otherwise alkalinizes thevagina.GoalTo test the efficacy of BufferGel for preventing sexuallytransmitted infections and pregnancy in animalmodels.Study DesignAnimals were challenged with pathogens or sperm afterpretreatment with both test and control agents, or after no pretreatment, thenevaluated for infection or pregnancy using standardmethods.ResultsBufferGel provided significant contraceptive efficacy inthe rabbit, and significant protection against vaginal and rectal transmissionof herpes simplex virus type 2 (HSV-2) in the mouse, vaginal transmission of Chlamydia trachomatis in the mouse,and skin transmission of cottontail rabbit papillomavirus in the rabbit. Itdid not protect against vaginal transmission of Neisseria gonorrhoeae in themouse.ConclusionsThe protective efficacy of BufferGel in five of the sixanimal models suggests that this microbicide warrants clinical evaluation forboth contraception and diseaseprevention.

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