Biologic Factors Affecting Spinal Fusion and Bone Regeneration

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Abstract

Study Design

Literature review.

Objectives

This article reviews the existing date on the multiplicity of iocal and systemic factors affecting lumbar spinel fusion and the general biology of bone regeneration.

Summary of Background Data

Arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. There exists a paucity of knowledge about the basic biology involved in achieving a successful fusion.

Methods

Medline and manual search of all relevant articles were performed and summarized.

Results

The success or failure of spinal fusion may be influenced by a hosl of local and systemic factors.

Conclusions

Future research should focus on expanding our existing knowledge pertaining to the basic bio'ogy of bone regeneration specific to spinal fusion.

Conclusions

Future research should focus on expanding our existing knowledge pertaining to the basic bio'ogy of bone regeneration specific to spinal fusion.

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