Theophylline: Constant-Rate Infusion Predictions

Abstract

This study was undertaken to evaluate a method of prospectively estimating appropriate aminophylline infusion rates in acutely ill, hospitalized patients with bronchospasm. Steady-state serum theophylline concentrations (Css), clearances (Cl), and half-lives (t1/2) were estimated by the Chiou method using serum concentrations obtained 1 and 6 h after the start of a constant-rate intravenous aminophylline infusion in 10 male patients averaging 57 years of age. Using an enzyme-multiplied immunoassay (EMITR system for theophylline analysis, pharmacokinetic estimations were excellent for Css (r = 0.9103, p < 0.01) and Cl (r = 0.9750, p < 0.01). The mean estimation errors were 9.4% (range 0.8–21.5) for Css and 12.3% (range 1.3–28.0) for Cl. There was no correlation between patient age and Cl. This method is useful for rapidly individualizing aminophylline therapy in patients with acute bronchospasm.