Issn Print: 0163-4356

Publication Date: 1997/10/01


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231 DETECTION AND QUANTIFICATION OF LICIT AND ILLICIT DRUGS IN SERUM BY ToF-SIMS

F. Saldi; R. Wennig; S. Schneider; H. N. Migeon

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Author Information: Laboratoire d'Analyse des Matériaux, Centre Universitaire de Luxembourg, 162A av. de la Faïencerie, L-1511 LUXEMBOURG

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Excerpt

Detection and quantification of drugs in biological samples is often time consuming due to the need of extensive sample treatment. A one step method for detection and quantification of drugs in serum (and other biological specimens) represents an important progress in emergency situations and reduces experimental errors during specimen handling.
High performance time of flight secondary ion mass spectrometry (ToF-SIMS) characterised by high mass resolution and low limit of detection has been applied to the detection of e.g. morphine and metabolites in human serum and urine specimens. Optimum emission of secondary ions is obtained from silver substrates covered by only a mono or submono-layer of molecules.
The limit of detection for morphine has been found to be less than 0.01 mg/L. Quantification range is of the same order of magnitude.

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