MARROW TRANSPLANTS IN LETHALLY IRRADIATED DOGS: THE EFFECT OF METHOTREXATE ON SURVIVAL OF THE HOST AND THE HOMOGRAFT*

Abstract

SUMMARY

Twenty dogs were given 1500 r whole-body irradiation and an infusion of homologous marrow. Ten dogs treated with methotrexate were compared with 10 dogs that received no drug therapy. The dogs given methotrexate showed an increased incidence of graft “take”, a decreased incidence of graft rejection, and an increased number of long-term survivors.