PROSTAGLANDIN AS AN EFFECTIVE ANTIREJECTION THERAPY IN RAT RENAL ALLOGRAFT RECIPIENTS


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Abstract

Became adenylate cyclase activators such as prosta-glandin E1 elevate lymphocytic cyclic AMP and inhibit T cell proliferation and the effector function of cytotoxic T cells in vitro, we tested the efficacy of 15(S)-15-methyl prostaglandin E1, a prostaglandin derivative with a prolonged biologic half-life. Treatment with this agent resulted in a near complete protection of renal grafts from immunologic damage, despite withholding therapy until day 4 following transplantation.

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