IMMUNOLOGICAL TOLERANCE IN HUMAN TRANSPLANTATION: THE POSSIBLE EXISTENCE OF A MATERNAL EFFECT


    loading  Checking for direct PDF access through Ovid

Abstract

We analyzed data from 93 patients who received a kidney graft from their parents: 55 were transplanted with a kidney from their mothers (Mat.) and thirty-eight from their fathers (Pat.) The Pat. group has shown a better graft and patient survival as well as long-term renal function when compared with the Mat. group. This pattern was more evident with time.Long-term graft function assessed by creatinine levels also showed differences between the groups, favoring that Pat. group. The results are interesting since recent reports have claimed a tolerance developed by the individual to noninherited HLA antigens of their mother.

    loading  Loading Related Articles