Recurrent Immunoglobulin A Nephropathy After Renal Transplantation: A Significant Contributor To Graft Loss1

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Background.Although most transplanted patients with underlying IgA nephropathy(IgAN) develop histological recurrence, its clinical relevance is considered low.Methods.We performed a single-center analysis of 61 renal transplant patients with IgAN.Results.Forty-four percent of the patients showed a stable graft function. Progressive graft dysfunction apparently due to recurrent IgAN occurred in 23% of the patients (16% required dialysis). Five patients were retransplanted, and three again developed dialysis-dependent renal failure apparently due to recurrent IgAN. In 20% of the patients, chronic transplant dysfunction was due to other reasons, whereas no reason was identified in 13% of the patients. Neither findings before transplantation, the ACE genotype, the type of immunosuppression, nor the course after transplantation predicted transplant dysfunction due to recurrent IgAN. Follow-up after transplantation was longer in the group with dysfunction due to recurrent disease than in the group with dysfunction due to chronic rejection or in the stable group.Conclusion.Recurrent IgAN is a clinically relevant problem in renal transplant patients. Its importance may have been underestimated in the past due to inadequate lengths of follow-up.

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