DOI: 10.1097/01.tp.0000225755.11560.15

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Issn Print: 0041-1337

Publication Date: 2006/07/15


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Early Loss of Two Renal Grafts Obtained from the Same Donor: Role of Ecstasy?

John A. McIntyre; Dawn R. Wagenknecht

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Excerpt

We read with interest the recent Transplantation paper by Dr. Hurault de Ligny et al. that describes early loss of renal grafts and a putative role for Ecstasy (1). We noted that their second hypothesis, hemostasis abnormalities, cites that antiphospholipid antibodies (aPL) were negative. We would like to ask the authors how many aPL specificities and isotypes were assessed?
The two patients described in this report were receiving peritoneal dialysis prior to renal transplant. Our studies have shown that aPL-positive renal patients using peritoneal dialysis are at grave risk for renal transplant failure (2). We have found antiphosphatidylethanolamine (aPE) and antiphosphatidylcholine (aPC) associated with kidney transplant failure (3). Did they test for these particular aPL specificities? We note that often IgG and IgM aCL are the only aPL assessed in published studies.
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