Evaluation of Reliability and Validity of Spanish Version of the End-Stage Renal Disease Symptom Checklist–Transplantation Module

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Although health-related quality of life (HRQoL) of patients with a renal transplantation is an important variable, it has received little attention and only a few Spanish validated measurement instruments are available. The aim of this study was to assess the psychometric properties of the Spanish version of the End Stage Renal Disease Symptom Checklist–Transplantation Module (ESRD-SCL), a specific questionnaire for measuring HRQoL of kidney transplant patients.


This prospective study to validate the ESRD-SCL included 307 patients who received a first kidney transplant. Patients filled out the ESRD-SCL, the EuroQol-5D and the Short Form-36 Health Survey at pretransplant, after 3 months, 6 months, and 1 year of follow-up. A complete set of sociodemographic and clinical data was also collected.


Mean age of patients was 51.6 years (SD±12) and 59.2% were men. A total of 24% had suffered initial allograft dysfunction and 18% had acute rejection. A six-dimensional factorial structure could be discerned. These dimensions were different from the original questionnaire and explained 56.07% of the variance. Internal consistency was good (Cronbach α = 0.91 for the overall score and 0.60–0.86 for dimensions). A statistically significant moderate correlation was observed between the Short Form-36 and EuroQol-5D with the ESRD-SCL dimensions and with some of the clinical and sociodemographic variables.


The Spanish version of the ESRD-SCL is a useful, user-friendly instrument for measuring the HRQoL related to the side effects on immunosuppression treatment of renal transplant patients more accurately.

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