Dialysis for end-stage renal disease

Abstract

Peritoneal dialysis is the major renal replacement therapy for children with end-stage renal disease, with hemodialysis used for a substantial number of pediatric patients. Reduction of morbidity and mortality is a major goal with the use of these modalities. Adequacy of dialysis and maintenance of peritoneal membrane function are important considerations for children on long term dialysis. Both adequacy and function are important to ensure optimal growth and nutrition and improve morbidity in this population. Use of supplemental gastrostomy tube feeds has improved calorie-protein malnutrition. Therapy advancements, such as growth hormone and erythropoietin, have improved the quality of life for dialysis patients. As the survival of the pediatric patient with end-stage renal disease improves, issues regarding cardiovascular disease and other factors that increase mortality in the adult population will need to be addressed.