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To further evaluate the usefulness of the Human Activity Profile (HAP) as a functional performance measure for those with chronic obstructive pulmonary disease (COPD).Phase 1. The sample consisted of 53 outpatients (51 male) with stable COPD (forced expiratory volume in 1 second% predicted (FEV1% pred) = 38 ± 14 (mean ± standard deviation) at a university-affiliated veterans affairs medical center. Variables were functional performance (HAP Maximal Activity Score [MAS], HAP Adjusted Activity Score [AAS]), dyspnea (modified Borg category-ratio scale and Shortness of Breath Questionnaire [SOBQ]), and exercise capacity (6-minute walk distance [6MWD]). Phase 2. The HAP was administered pre-post pulmonary rehabilitation in 48 (14 male) outpatients with stable COPD (FEV1% pred = 35 ± 15) at an outpatient pulmonary rehabilitation program at a large private hospital.Phase 1. Scores for MAS and AAS were, respectively, 62 ± 12 and 44 ± 15. The 6MWD, modified Borg, and SOBQ were, respectively, 1055 ± 372 ft, 4.1 ± 1, and 64.4 ± 22 ft. Correlations of the 6MWD and dyspnea scores with the AAS were strong and explained 40% of the AAS variation. Phase 2. The baseline MAS and AAS scores were 55 ± 14 and 42 ± 15, respectively, with 29/48 (60%) classified as “low fitness” on the basis of the AAS. Post-rehabilitation, there was significant improvement in the AAS score (48 ± 13) and significant reduction for those classified as “low fitness.”The utility of the HAP as a measure of functional performance improvement in COPD is supported by its relationship with both 6MWD and dyspnea and its responsiveness to pulmonary rehabilitation.