Issn Print: 0955-8810

Publication Date: 2005/09/01


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A54 NEUROPROTECTIVE EFFECT OF NOOGLUTYL IN RATS WITH EXPERIMENTALLY PRODUCED HEMORRHAGIC STROKE

I.P. Galaeva; T.A. Voronina; T.L. Garibova

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The present investigation was carried out with purpose of examining the neuroprotective properties of nooglutyl [N-(5-oxinicotinoyl)-L-glutamic acid], an agent with nootropic and antihypoxic activity, and a positive modulator of the α-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) subtype of glutamatergic receptors. The study used the models of intracerebral post-traumatic hematoma (hemorrhagic stroke) in rats. The hemorrhagic stroke (HS) was produced in animals by cerebral tissue destruction in the internal capsule region.
Nooglutyl was administered as single doses of 10 mg/kg and 20 mg/kg i.p. 3 h after the operation. It was established that the agent diminished HS-induced neurological deficit and movement coordination disturbances, and improved the reproduction of conditioned passive avoidance reflex (PAR). Nooglutyl, especially at a dose of 10 mg/kg, was found to prevent the animal death caused by HS. Morphological studies revealed the hemorrhages on both sides of the internal capsule in animals with HS, whereas in the neurocortex a large amount of neurons with ischemia-induced changes were observed. Nooglutyl was found to diminish the changes in cortical neurons of rats following HS. With nooglutyl, PAR retrieval disorders were much less pronounced. The results obtained from these studies provided fair evidence of neuroprotective and memory-restoring properties of nooglutyl in modele of hemorrhagic stroke.

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