DOI: 10.1097/01.RUQ.0000302228.21864.d7
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Issn Print: 0894-8771
Publication Date: 2008/03/01
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Excerpt
The purpose of this study was to identify and validate a Doppler scoring system of breast cancer lesions for prognosis, in assessing and predicting response to chemotherapy treatment.
Fifty patients with locally advanced breast cancer (T3 or T4 lesions) receiving neoadjuvant chemotherapy were included in this study. Patients were evaluated cyclically before chemotherapy and surgery.
Ultrasound examinations were performed using an 11-MHz probe using standardized settings optimized to detect low flow and low velocity. Spectral Doppler imaging and conventional Doppler imaging were performed with evaluation of peak flow velocity, resistive index, and peak systolic velocity.
Twenty-two (44%) and 18 (36%) of the 50 patients showed regression in resistive index and peak flow velocity, respectively.
The authors conclude that Doppler scoring can be accurately used to predict response to chemotherapy in patients with locally advanced breast cancer, with higher indices corresponding to a better histological response.
